NEW PERSPECTIVES OF GENE THERAPY ON POLYGLUTAMINE SPINOCEREBELLAR ATAXIAS: FROM MOLECULAR TARGETS TO NOVEL NANOVECTORS

New Perspectives of Gene Therapy on Polyglutamine Spinocerebellar Ataxias: From Molecular Targets to Novel Nanovectors

Seven of the most frequent spinocerebellar ataxias (SCAs) are caused by a pathological expansion of a cytosine, adenine and guanine (CAG) trinucleotide repeat located in exonic regions of unrelated genes, which in turn leads to the synthesis of polyglutamine (polyQ) proteins.PolyQ proteins are prone to aggregate and form intracellular inclusions, w

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Understanding the notion of function and articulation of semiotic records that represent between students entering a program Engineering

This study aims to assess the understanding of the notion of function and the ability to articulate different semiotic registers for representation by new students in the university in Colombia.Immediate Toiletry Bags context is taken as the Faculty of Engineering at a public university.Epistemologically the study is based on symbolic interaction b

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